Tuesday October 17, 2006


Q; So what should be the target vancomycin trough (or random) level ?

A: This month a retrospective study of 102 patients with MRSA has been published into 'chest' looking into benefit of higher vancomycin trough or random level (more than 15 µg/mL). The stratification of the vancomycin trough levels yielded no relationship with hospital mortality. Study found no evidence that higher vanco trough levels correlated with hospital outcome.

'Vanco level' between 5 to 15 µg/mL seems to be a reasonable target range.


Reference: click to get abstract

Predictors of Mortality for Methicillin-Resistant Staphylococcus aureus Health-Care–Associated Pneumonia - Specific Evaluation of Vancomycin Pharmacokinetic Indices - Chest. 2006;130:947-955.